Role of insulin in the state of ketosis
To understand how ketones, are produced, it is first important to briefly note the role of insulin. When carbohydrates are consumed, the pancreas releases insulin due to elevated blood glucose levels. Insulin is a hormone that provides a signal to tissues to absorb excess blood glucose; glucose is then stored as glycogen or converted into and stored as fat. Chronically high levels of glucose circulating in the bloodstream are harmful and, as a result, insulin protects our body against glucose damage. However, when insulin levels are even slightly elevated, stored fat can not be broken down and used for energy. In addition, dietary fats will be stored.
Carbohydrate consumption raises blood sugar, eventually increasing insulin levels. Insulin prevents the fat cells from entering the bloodstream to be used as energy, so it stays stored in the body. When you reduce your carbohydrate intake, blood sugar and insulin levels drop, forcing your body to look for an alternative source of energy. Excess glucose that has been converted to glycogen is depleted after 1-2 days of a restricted carbohydrate diet and then turns into fat storage. Entering the metabolic state known as ketosis, your body begins to use ketones, the energy source produced by the liver as it degrades fat. To maintain a ketogenic diet is done with a diet rich in low fat carbohydrates. This can be difficult for some, so exogenous ketone supplementation helps you maintain a higher rate of ketones in your body!
In a diet rich in carbohydrates (carbs – carbohydrates), the body does not see the need to produce and use ketone bodies to its full potential. Yet these molecules are naturally present in the body that are responsible for fat burning, 9 kilocalories / gram. The body prioritizes carbohydrates, 4 kilocalories / gram, as a source of energy due to the abundance of these last in our current lifestyle. He therefore puts on hold the production of ketones to spend the fastest energy source available (carbohydrates).
The ketogenic diet ideally minimizes the consumption of carbohydrates from 20 to 50 grams per day, favoring foods with low glycemic index. Vegetables largely meet this requirement, in addition to being rich in fiber. Since the body is deprived of carbohydrates as the main source of energy, it self-adapts by activating the state of ketosis (production of ketone bodies to burn fat), also called nutritional ketosis.
Do you think you eat a little carbohydrate? Go see, the amount of carbohydrates in your bread … You will be surprised!
In a state of ketosis, your body resumes the production of ketone bodies and burns the fats (triglycerides) stored and consumed. The main source of energy in your body adapts (being deprived of carbohydrates) to thus exploit the fat at their full potential and become a machine to burn fat.
Source: Dr. Stephen Phinney – ‘The Art and Science of Low Carb Living and Performance’
The caveman was eating meat (protein and fat). Our brain has developed with lipids, not carbohydrates. When carbohydrates are limited in the diet due to fasting or a very low carbohydrate diet, the release of insulin by the pancreas decreases considerably. This means that the body is not in a storage state and therefore stored fuel stores such as glycogen and fats can be broken down to produce energy. Once the glycogen is depleted, usually after the 1st or 2nd day of carbohydrate restriction, the fatty acids are highly counted to feed the tissues. Individuals can elevate ketone bodies in circulation by long-term fasting or by chronically limiting dietary carbohydrates.
The brain is the body’s fatest organ (60% of brain tissue is adipose tissue). It isolates neurons and allows messages to travel through the brain and the body. A big brain is a healthy brain. While your brain accounts for about 2-3% of our total weight, 25% of the cholesterol in our body is in the brain, where it plays an important role in the function of the membrane, acts as an antioxidant and serves as a raw material for what we are able to do such as progesterone, estrogen, cortisol, testosterone and even vitamin D.
Ketosis is a metabolic state in which most of the body’s energy intake comes from fat bodies broken down into ketones in the blood, unlike a state of glycolysis where blood glucose provides most of the energy. Ketosis is characterized by serum ketone body concentrations greater than 0.5 mmol / L with low and stable levels of insulin and blood glucose. University research suggests that exogenous ketone supplements can induce ketosis, even when there are normal levels of glucose in the blood. Ketosis contrasts with ketosis, or nutritional ketosis, which is the production of ketones in the liver through a process by which ketones are produced as a result of fatty acid degradation. When taking exogenous ketones, ketone supplementation essentially replaces ketogenesis and only the bioavailability of ketones in the blood for cell use creates the ketosis state. Nutritional ketosis usually starts at 0.5 mmol / L and is optimized between 2.0 mmol / L and 3.6 mmol / L. This is what we call the ZONE.
Ketones are natural compounds formed in the liver and include β-hydroxybutyrate, acetoacetate and acetone. Similar to carbohydrates and fats, ketone bodies can provide energy for our cellular needs. They are produced in the liver when 1) glucose levels are low and the pathway that breaks down glucose slows down, and 2) high levels of fatty acids are available either from dietary fat or fat stores. Fatty acids can be completely decomposed to provide energy directly to certain tissues or they can be partially broken down and transported to the liver. In the liver, these partially degraded fatty acids are then converted into ketone bodies by a pathway called ketogenesis. Ketones are soluble in water unlike fatty acids, so they travel easily through the bloodstream to reach other tissues to use as fuel. The brain uses ~ 100% glucose for energy when carbohydrates are present in the diet. However, when ketones are present, the brain can derive up to 60% of its energy directly from the ketone bodies. The liver can convert substrates such as proteins into glucose (that is, gluconeogenesis) which can then feed the remaining 40% of brain energy during carbohydrate restriction. All cells have the ability to use ketone bodies, with the exception of liver and red blood cells, but some cells prefer ketones. In addition to the brain, the heart and intestines also prefer to use ketone bodies as fuel.
The supplements of Ketones help the body to reach and remain in a state of ketosis. Exogenous ketones are approved by Health Canada. It is important if you choose to consume Ketones to limit yourself to one or two a day. More and more specialists are interested and recommend this diet which is absolutely not restrictive, that is to say that one does not count the lipids and proteins, only the carbohydrates.
- Reduction of oxidative stress and inflammation
- Reduced anxiety and depression
- Improvements in conditions such as epilepsy, Parkinson’s disease, Alzheimer’s disease, polycystic ovary syndrome, diabetes, obesity, cardiovascular disease and cancer
- Improvement of body composition
- Make better food choices: Ketones naturally decrease your appetite, allowing you to make better choices and eat less often.
- Minimize sugar consumption: Ketones do not require insulin to provide energy to your cells as does glucose, so blood sugar levels are regulated and minimized, which helps eliminate cravings and excesses.
- Protect muscles: Ketones are extremely anti-catabolic (they preserve protein and muscle), preserve and protect your lean tissue during periods of caloric restriction. The more muscle you keep, the more fat you burn.
- Move more: Ketones offer insulin-free energy that maximizes your mindset and mental focus while motivating you to move more, do more and be more.
- Energy production: Ketones produce more TPA (Triphosphate Adenosine) per unit of oxygen than glucose, which makes the workouts more efficient.
- Inflammation: Ketones have incredible anti-inflammatory properties that facilitate and improve post-workout recovery.
- Endurance: The Dual Fuel operating system (Ketones and Glucose) delays the release of glycogen stored in the muscles. This allows for larger, longer, and stronger performance.
- Signalisation: Les cétones sont connus pour provoquer de nombreux effets bénéfiques en agissant sur les défenses antioxydantes protectrices de notre corps.
- Signaling: Ketones are known to cause many beneficial effects by acting on the protective antioxidant defenses of our body.
- Endurance: Exogenous ketones can help maximize endogenous ketone production in the body, leading to improved biomarkers, including blood glucose, cholesterol, triglycerides, and blood pressure.
Substantially reduce your carbohydrate consumption, otherwise you will be disappointed with the results. A change in your lifestyle is essential. Ketone supplements alone are not a system to lose weight, they must be coupled with a decrease in carbohydrates. Ketones bring, among other things, mental clarity, muscle retention, faster recovery, decreased appetite, strength gain, better sleep, better digestion, clearer skin, better concentration to help you keep the focus and increase your energy level. In addition, it has been proven (see testimonials) that ketogenic diet contributes to the reduction of cholesterol, type 2 diabetes, cancer … A significant improvement has been observed in cases of degenerative diseases.
To optimize the benefits of ketones in your body, your cocktail of exogenous ketones should ideally be consumed within a maximum of 15 to 20 minutes.
En adoptant un régime de vie sain,
l’on voit des améliorations dans toute notre organisme…
To summarize, they contribute to:
- Weight Loss (1)
- Preservation of muscle mass (2)
- Energy support (3)
- Increased focus (4)
- Decreased appetite (5)
- Strength gain
- Better mood
- Better sleep
- Meilleure digestion
- Lighter skin
- Can promote better digestion
- Will not promote lipogenesis
- High and sustained energy
- Promotes thermogenesis
- Can provide neuroprotection and increase brain activity
- Promotes the reduction of triglycerides
- Improves neurological effiectiveness
- Can reduce free radicals
- Promotes relaxation and reduces stress
- Improves metabolism
The achievement of this state, however, requires a delay called keto adaptation. Many people, motivated at first, abandon the ketogenic lifestyle by discouragement in response to the sometimes unpredictable reactions of the body or lack of information.
Science now offers tools to reach the state of ketosis faster. This is where ketone supplements (ketones) will help you make the transition to your new lifestyle.